This is important because the effects of activating these receptors can be quite noticeable. For instance, some studies have found that activation of CB2 receptors can rid the brain of beta-amyloid protein – a plaque found in people with Alzheimer’s disease while activation of CB1 receptors can positively impact depression, reduce fear and paranoia, and lower intestinal inflammation and blood pressure. CB1 receptor activation can even give relief to one of the most prevalent mental disorders in the United States – anxiety.